About Dengue Vaccines
Dengue is a viral disease transmitted by infected mosquitoes, particularly female mosquito of Aedes aegypti responsible vector to transmit the virus that causes dengue. Dengue causes sudden fever and pain in the joints. While vaccines are preventive measures taken to cure any disease by facilitating immunity to develop protection from disease. It is a biological preparation that provides active acquired immunity, vaccines are consisting of substance-related to disease-causing microorganism and are sometimes made from weak or killed forms of the microbe, its toxins, or its proteins. Dengue vaccine is mainly CYD tetravalent dengue vaccine from Sanofi Pasteur (France)is leading for dengue vaccines. A live attenuated vaccine known as Dengvaxia, developed by Sanofi, launched and approved license in 2015. Dengvaxia is a mixture of four monovalent chimeric vaccine viruses, CYD-1, CYD-2, CYD-3, and CYD-4, produced using Vero cells. These four CYDs are based on the yellow fever virus (YFV) 17D vaccine vector backbone. First licenses approved in Mexico in 2015 for 9-45 individuals for 20 countries.
Attributes | Details |
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Study Period | 2018-2028 |
Base Year | 2022 |
Unit | Value (USD Million) |
The leading pharmaceutical companies are working on their research and development team to clear all the clinical trials and get approval from the FDA to launch its vaccines. Therefore the competition is now with research teams of different manufactures to get the company profit and business. There is also an option available like mergers and acquisitions of a different firm to enhanced the research and technological enhancement of the companies. Analyst at AMA Research estimates that Asia Pacific Players will contribute the maximum growth to Global Dengue Vaccines market throughout the forecasted period. Established and emerging Players should take a closer view at their existing organizations and reinvent traditional business and operating models to adapt to the future.
Sanofi Pasteur Inc (France), Merck & Co Inc (United States), GlaxoSmithKline (United Kingdom ), Pfizer (United States), Instituto Butantan (Brazil), Takeda Pharmaceutical Company Limited (Japan), Sun Pharmaceutical Industries Limited (India), GeneOne Life Science Inc (South Korea), Medigen Vaccine Biologics Corporation (China) and Merck Sharp & Dohme (United States) are some of the key players that are part of study coverage. Additionally, the Players which are also part of the research coverage are Vabiotec (Vietnam) and Panacea Biotec Limited (India).
Segmentation Overview
AMA Research has segmented the market of Global Dengue Vaccines market by , Application (Prevention of dengue and Enhanced the immunity) and Region.
On the basis of geography, the market of Dengue Vaccines has been segmented into South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Taiwan, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico). If we see Market by End Users, the sub-segment i.e. Government organizations will boost the Dengue Vaccines market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth. If we see Market by Vaccines, the sub-segment i.e. Live Attenuated Vaccines will boost the Dengue Vaccines market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth.
Influencing Trend:
Two New Live Attenuated Dengue Vaccines Are Currently In Phase Iii Efficacy Trials and Dsv4 Process Development And Scale-Up Work Are Currently In Progress
Market Growth Drivers:
Growing Demand due to Rising in Infection Level
Challenges:
Dengue Vaccines Are Challenged By Critical Issues Like Lack Of Animal Models For The Disease And Absence Of Suitable Markers Of Protective Immunity, New Advances In Dengue Pathogenesis And Immune Response Will Shed Light On The Approach Needed To Make An Ideal Dengue Vaccine and Dengue Vaccines Banned In Philippines Due To Controversy
Restraints:
The Lack Of An Appropriate Animal Model That Elucidates The Pathogenesis, Immune Response And Clinical Course Of Dengue Infection In Humans, Unsuitable For Studying Immune Responses In Dengue Vaccine Pre-Clinical Trials and Sometimes Side Effects Related To Dengue Vaccines Are Severe
Opportunities:
Highly Demanded In Rainy Season
Market Leaders and their expansionary development strategies
In July 2023, Takeda Pharmaceutical Company and PATH has Announced a partnership to accelerate access to Takeda's dengue vaccine, TAK-003, in low- and middle-income countries (LMICs). This partnership will focus on supporting regulatory approval, building healthcare worker capacity, and increasing vaccine awareness in LMICs.
In October 2023, Takeda Pharmaceutical Company has Announced positive Phase III clinical trial results for its dengue vaccine candidate, TAK-003. The vaccine demonstrated 80.2% efficacy against all dengue serotypes in 6-16 year olds, and 90.1% efficacy in those who had previously been infected with dengue.
On 1st May 2019, the FDA approves the first vaccine for dengue fever, but with major restrictions. The Food and Drug Administration approved the first vaccine against dengue fever, one that protects against a common disease but has generated significant controversy due to evidence it can increase the risk of severe infection in some people. Dengvaxia was licensed in 2015. But it caused a major scandal two years ago in the Philippines. After nearly a million Filipino children had been vaccinated with Dengvaxia, the drug's manufacturer, Sanofi, announced that the inoculation might make dengue worse in some people.
Key Target Audience
Manufacturers, Hospital and diagnostic centers, Distributors/Suppliers/Wholesalers, Government sector, Research firms, Clinical Trial Centres and Downstream Vendors
About Approach
To evaluate and validate the market size various sources including primary and secondary analysis is utilized. AMA Research follows regulatory standards such as NAICS/SIC/ICB/TRCB, to have a better understanding of the market. The market study is conducted on basis of more than 200 companies dealing in the market regional as well as global areas with the purpose to understand the companies positioning regarding the market value, volume, and their market share for regional as well as global.
Further to bring relevance specific to any niche market we set and apply a number of criteria like Geographic Footprints, Regional Segments of Revenue, Operational Centres, etc. The next step is to finalize a team (In-House + Data Agencies) who then starts collecting C & D level executives and profiles, Industry experts, Opinion leaders, etc., and work towards appointment generation.
The primary research is performed by taking the interviews of executives of various companies dealing in the market as well as using the survey reports, research institute, and latest research reports. Meanwhile, the analyst team keeps preparing a set of questionnaires, and after getting the appointee list; the target audience is then tapped and segregated with various mediums and channels that are feasible for making connections that including email communication, telephonic, skype, LinkedIn Group & InMail, Community Forums, Community Forums, open Survey, SurveyMonkey, etc.