About RNAi for Therapeutic
RNAi also known as Post-Transcriptional Gene Silencing (PTGS) is a conserved biological response to double-stranded RNA that mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNA is a natural biological process that regulates gene expression by “interfering” with messenger RNA (mRNA), which carries DNA’s instructions for making new proteins. RNAi therapeutics is an innovative new class of medicines based on RNA interference (RNAi)—a breakthrough discovery in understanding how genes are regulated naturally within cells.
Attributes | Details |
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Study Period | 2017-2027 |
Base Year | 2021 |
Unit | Value (USD Million) |
The market for RNAi for Therapeutic is highly competitive with several global as well as local players in the market. The global players are trying various strategies such as product innovation and using various marketing strategies to gain a higher market share. Analyst at AMA Research estimates that United States Players will contribute the maximum growth to Global RNAi for Therapeutic market throughout the forecasted period. Established and emerging Players should take a closer view at their existing organizations and reinvent traditional business and operating models to adapt to the future.
Ionis Pharmaceuticals (United States), Moderna (United States), Vir Biotechnology, Inc. (United States), Alnylam Pharmaceuticals (United States), BOC Sciences (United States), Akcea Therapeutics (United States), Abogen Biosciences (China), Arrowhead Pharmaceuticals (United States), laronde therapeutics (United States) and Sarepta Therapeutics (United States) are some of the key players that are part of study coverage. Additionally, the Players which are also part of the research coverage are Nutcracker Therapeutics (United States), Deep Genomics (Canada), Sirnaomics (United States), Gotham Therapeutics (United States), Quark Pharmaceuticals (Israel), Gradalis (United States), CureVac (Germany) and BioNTech (Germany).
Segmentation Overview
AMA Research has segmented the market of Global RNAi for Therapeutic market by Type (small interfering RNAs (siRNA) and short hairpin RNAs (shRNA)), Application (Neurodegenerative Disease, Cardiovascular Disease, Viral Infection, RNAi-Based Tumor Treatment and Cancer) and Region.
On the basis of geography, the market of RNAi for Therapeutic has been segmented into South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico). If we see Market by End User, the sub-segment i.e. Hospitals will boost the RNAi for Therapeutic market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth.
Influencing Trend:
Technological Penetration and New Innovation in RNAi for Therapeutic
Market Growth Drivers:
Surge in Demand in Laboratories Gene Interfering in Genome, Demand in Therapy of Muscular Degeneration, Rising Demand in Treatment of Respiratory Infections and Rising demand in New drug and Medicine development
Challenges:
Lack of Acceptance in Clinical Practice Due To Low Stability And Drug Delivery, Lack of Technological Standards for RNAi Therapeutic, Complicated and Complex Therapy Procedure and Lack of Skilled Professional for RNAi Therapeutic
Restraints:
Lack Of Delivering An Efficacious Doses Of The RNAi-Triggering Molecules To The Target Tissue
Opportunities:
Growth in Medical Research and Development and Continuous Development in Healthcare Infrastructure
Market Leaders and their expansionary development strategies
On 3 April 2020, Vir Biotechnology, Inc. and Alnylam Pharmaceuticals, Inc announced an expansion of their existing collaboration to include the development and commercialization of RNAi therapeutics targeting SARS-CoV-2, the virus that causes the disease COVID-19. Under the agreement, the companies will utilize Alnylam’s recent advances in lung delivery of novel conjugates of siRNA – the molecules that mediate RNAi – together with Vir’s infectious disease expertise and established capabilities, to bring forward one or more siRNAs to treat SARS-CoV-2 and potentially other coronaviruses as well. The collaboration will focus on development of siRNAs that Alnylam recently identified that target highly conserved regions of coronavirus RNAs.
On 28 December 2020, BOC RNA announced the expansion of its existing cooperation scope, including the development and commercialization of RNAi therapeutic drugs. The company will use its latest progress in targeted delivery of siRNA drugs and its established capabilities to deepen the development of RNAi drugs for tumors and neurological diseases.
Key Target Audience
RNAi for Therapeutic, New Entrants and Investors, Venture Capitalists, Government Bodies, Corporate Entities, Government and Private Research Organizations and Others
About Approach
To evaluate and validate the market size various sources including primary and secondary analysis is utilized. AMA Research follows regulatory standards such as NAICS/SIC/ICB/TRCB, to have a better understanding of the market. The market study is conducted on basis of more than 200 companies dealing in the market regional as well as global areas with the purpose to understand the companies positioning regarding the market value, volume, and their market share for regional as well as global.
Further to bring relevance specific to any niche market we set and apply a number of criteria like Geographic Footprints, Regional Segments of Revenue, Operational Centres, etc. The next step is to finalize a team (In-House + Data Agencies) who then starts collecting C & D level executives and profiles, Industry experts, Opinion leaders, etc., and work towards appointment generation.
The primary research is performed by taking the interviews of executives of various companies dealing in the market as well as using the survey reports, research institute, and latest research reports. Meanwhile, the analyst team keeps preparing a set of questionnaires, and after getting the appointee list; the target audience is then tapped and segregated with various mediums and channels that are feasible for making connections that including email communication, telephonic, skype, LinkedIn Group & InMail, Community Forums, Community Forums, open Survey, SurveyMonkey, etc.