What is Anti-Neprilysin Market Scope?
Neprilysin inhibitors hereby cause an increase in natriuretic peptides, which are mainly important for maintaining fluid as well as sodium balance through natriuresis, diuresis, and vasodilation. This lowers blood pressure and effectively treats heart failure. Neprilysin can be used in combination with other medications to improve treatment for heart failure. Therefore, anti-neprilysin drugs are used to treat high blood pressure, heart failure, kidney disease, and others. Sacubitril / Valsartan is used instead of an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) and in conjunction with treatment when it does not work in patients with heart disease. The inhibition of neprilysin helps increase the level of natriuretic peptides. Neprilysin inhibitors help lower the risk of heart failure and lower blood pressure. The COVID-19 pandemic has significantly increased the demand for several drugs. The spread of coronavirus is also having a negative impact on sales for companies whose product demand is heavily reliant on selective disease treatments.
The Anti-Neprilysin market study is being classified by Type (TD-0714, STR-324, PL-265, LHW-090 and Others), by Application (Acute Heart Failure, Cancer Pain, Hypertension, Alzheimer's Disease and Others) and major geographies with country level break-up.
The companies are exploring the market by adopting expansions, investments, new service launches, and collaborations as their preferred strategies. The players are exploring new geographies through expansions and acquisitions across the globe to avail of competitive advantage through combined collaborations.
Bioprojet SCR (France), Novartis AG (Switzerland), Pharmaleads SA (France), Theravance Biopharma Inc. (United States), Cipla Limited (India) and Oceanic Pharmachem Pvt. Ltd. (India) are some of the key players profiled in the study.
Segmentation Analysis
Analyst at AMA have segmented the market study of Global Anti-Neprilysin market by Type, Application and Region.
On the basis of geography, the market of Anti-Neprilysin has been segmented into South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Taiwan, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico).
Market Influencers and their development strategies
On 02 March 2020, Otsuka Pharmaceutical Co., Ltd and Novartis Pharma execute an agreement for Novartis Pharma angiotensin receptor neprilysin inhibitor (ARNI) LCZ696 treatment for Chronic heart failure. As per the agreement, Novartis Pharma and Otsuka will work together to promote LCZ696 to healthcare professionals. Novartis Pharma will receive a JPY 10 billion upfront payment from Otsuka, as well as subsequent milestone payments. Novartis Pharma will pay Otsuka a promotion fee based on the product's sales. LCZ696 is a novel medication that decreases cardiac load in patients with chronic heart failure by activating a protective neurohormonal mechanism while reducing the detrimental effects of renin-angiotensin-aldosterone system overactivity (RAAS).
On 24 June 2020, Novartis announces USFDA accepted the supplemental new drug application of Entresto that contains an Anti-Neprilysin inhibitor inpatient with HFpEF and HFrEF for both chronic heart failure. Entresto is a prescription drug that helps people with long-term (chronic) heart failure minimize their risk of cardiovascular death and heart failure hospitalization (HFrEF). Entresto comprises sacubitril, a neprilysin inhibitor, and valsartan, an ARB. Entresto is a twice-daily prescription drug that works by increasing the positive neurohormonal systems while decreasing the negative effects of an overactive renin-angiotensin-aldosterone system.
The US Food and Drug Administration (FDA) had thereby approved Entresto (sacubitril/valsartan) for the purpose of treatment of symptomatic heart failure (HF) with systemic left ventricular systolic dysfunction in pediatric patients that are 1 year of age and older. Entresto reduces NT-proBNP and is believed to improve cardiovascular outcomes.
Influencing Market Trend
- Growing Awareness Regarding Neprilysin
- The Increasing Number of Clinical Trials of Anti-Neprilysin Drugs
- Favorable Reimbursement Policies
- Rising Trend in Consumption of Foods High In Sodium, Cholesterol, and Fats; and Smoking of Tobacco
Market Drivers
- The Increasing Prevalence of the Congestive Heart Failure All Over the Globe
- Rising Prevalence of Hypertension
- Lack of Enough Physical Activity
- The Growing Patient Pool and Increasing Technological Advancements
- Increasing Geriatric Population, And the Constantly Changing Lifestyle Habits
Opportunities
- Rising Healthcare Expenditure
- Increasing Initiatives Regarding Health Care by Governments
Restraints
- A Strong Pipeline and Product Approvals
Challenges
- Serious Side-Effects of Such Drugs
Key Target Audience
New Entrants/Investors, Analysts and Strategic Business Planners, Venture Capitalists, Government Regulatory, Research Organizations and End-Use Industry
Customization available in this Study:
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