About Limb Girdle Muscular Dystrophy
Limb-girdle muscular dystrophy is a term used for a group of diseases that cause weakness and muscle wasting in the arms and legs. The muscles most affected are the ones closest to the body (proximal muscles), particularly the muscles of the shoulders, upper arms, pelvic area, and thighs. The severity, age of onset, and characteristics of limb-girdle muscular dystrophy vary between the many subtypes of the disease and may even be inconsistent within the same family. Signs and symptoms can appear first at any age and generally worsen over time, although in some cases they can remain mild. The common features of LGMDs are the weakness and atrophy of the limb-girdle muscles. However, the age at which symptoms appear, and the rate and severity of disease progression can vary. There are two main groups of LGMDs. These two groups, called LGMD1 and LGMD2, are classified according to their inheritance patterns: autosomal dominant and autosomal recessive. There are few studies that confirm the effectiveness of exercise in muscular dystrophy of the limb-girdle. However, studies have shown that exercise can actually cause permanent damage to muscles due to strong muscle contraction.
Attributes | Details |
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Study Period | 2018-2030 |
Base Year | 2023 |
Unit | Value (USD Million) |
The companies are now exploring the market by adopting mergers & acquisitions, expansions, investments, new developments in existing products, and collaborations as their preferred strategies. The players are also exploring new geographies and industries through expansions and acquisitions so as to avail a competitive advantage through combined synergies. Analyst at AMA Research estimates that United States Players will contribute the maximum growth to Global Limb Girdle Muscular Dystrophy market throughout the forecasted period. Established and emerging Players should take a closer view at their existing organizations and reinvent traditional business and operating models to adapt to the future.
Myonexus Therapeutics, Inc. (United States), aTyr Pharma, Inc. (United States) and Sarepta Therapeutics (United States) are some of the key players that are part of study coverage.
Segmentation Overview
AMA Research has segmented the market of Global Limb Girdle Muscular Dystrophy market by Type (LGMD1 and LGMD2), Application (Hospitals, Clinics and Others) and Region.
On the basis of geography, the market of Limb Girdle Muscular Dystrophy has been segmented into South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Taiwan, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico). If we see Market by Treatment Type, the sub-segment i.e. Occupational Therapy will boost the Limb Girdle Muscular Dystrophy market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth. If we see Market by Diagnosis, the sub-segment i.e. Biopsy will boost the Limb Girdle Muscular Dystrophy market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth.
Influencing Trend:
Increasing Awareness Campaigns for LGMD and Emerging Demand from Economies
Market Growth Drivers:
Rising Disease Burden of Limb-Girdle Muscular Dystrophy, Growing Incidences of Orthopedic Disorders and Rising Geriatric Population and Unhealthy Lifestyle Habits
Challenges:
Growing Acceptance of Acupuncture and Yoga
Restraints:
Higher Cost and Maintenance of Physiotherapy Machines
Opportunities:
Rapid Technological Advancements & Product Innovation, Increasing Awareness among People and With the Government’s Urgency for the Treatment of the Disease and Increasing Investments in Biopharmaceutical R&D to Release Novel Disease Therapies
Market Leaders and their expansionary development strategies
In January 2023,Sarepta Therapeutics acquires gene therapy asset for Limb-Girdle Muscular Dystrophy Sarepta Therapeutics, a company specializing in gene therapies for neuromuscular diseases, acquired a gene therapy asset called SRP-9041 from Applied Genetic Technologies. SRP-9041 is being developed for the treatment of LGMD2E, another subtype of LGMD caused by mutations in the TCAP gene.
In February 2023, Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today announced that the first patient has been dosed in Study SRP-9003-102. Also known as VOYAGENE, Study 9003-102 is a phase 1 study of SRP-9003 (bidridistrogene xeboparvovec) for the treatment of limb-girdle muscular dystrophy Type 2E/R4 (LGMD2E). VOYAGENE is a U.S.-only study enrolling ambulant patients aged 18 years or older and non-ambulant patients, ages 4-50 years, using clinical process SRP-9003 material.
Key Target Audience
Providers of Limb-Girdle Muscular Dystrophy, End-Users, Potential Investors, Market Research Firms, Regulatory Bodies and Others
About Approach
To evaluate and validate the market size various sources including primary and secondary analysis is utilized. AMA Research follows regulatory standards such as NAICS/SIC/ICB/TRCB, to have a better understanding of the market. The market study is conducted on basis of more than 200 companies dealing in the market regional as well as global areas with the purpose to understand the companies positioning regarding the market value, volume, and their market share for regional as well as global.
Further to bring relevance specific to any niche market we set and apply a number of criteria like Geographic Footprints, Regional Segments of Revenue, Operational Centres, etc. The next step is to finalize a team (In-House + Data Agencies) who then starts collecting C & D level executives and profiles, Industry experts, Opinion leaders, etc., and work towards appointment generation.
The primary research is performed by taking the interviews of executives of various companies dealing in the market as well as using the survey reports, research institute, and latest research reports. Meanwhile, the analyst team keeps preparing a set of questionnaires, and after getting the appointee list; the target audience is then tapped and segregated with various mediums and channels that are feasible for making connections that including email communication, telephonic, skype, LinkedIn Group & InMail, Community Forums, Community Forums, open Survey, SurveyMonkey, etc.