About Targeted Protein Degradation
Over the past decades, continuous progress has been made towards understanding the bifunctional molecules(Physiochemical and biological properties), variety of other chemical entities and molecular glues have been developed for the treatment of a variety of clinical including, Alzheimer’s disease, breast cancer, psoriasis and many more, by enabling efficient hit discovery and characterization of potential therapeutics leads. Targeted Protein Degradation is stating to the use of heterobifunctional small molecule l degraders used to achieve knockdown of target proteins within cells, it consists of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. In addition, it represents an exciting new therapeutic opportunity to eliminate disease-causing proteins. Substantial advancements have been made in the discovery and development of clinically relevant degraders is booming the importance of targeted protein degradation in the market.
Attributes | Details |
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Study Period | 2017-2027 |
Base Year | 2021 |
Unit | Value (USD Million) |
The companies are now exploring the market by adopting mergers & acquisitions, expansions, investments, new developments in existing products, and collaborations as their preferred strategies. The players are also exploring new geographies and industries through expansions and acquisitions so as to avail a competitive advantage through combined synergies. Analyst at AMA Research estimates that United States Players will contribute the maximum growth to Global Targeted Protein Degradation market throughout the forecasted period. Established and emerging Players should take a closer view at their existing organizations and reinvent traditional business and operating models to adapt to the future.
5AM Venture (United States),, AbbVie Inc (United States), Almac Group (United Kingdom), Amgen Inc. (United States), Bayer AG (Germany), Biogen Inc. (United States), C4 Therapeutics (United States), Cosmo Bio USA (United States), Eli Lilly and Company (United States), Mission Therapeutics (United States) and Roivant Sciences (Switzerland) are some of the key players that are part of study coverage.
Segmentation Overview
AMA Research has segmented the market of Global Targeted Protein Degradation market by Type (Degronimids, IMiDs, PROTACs, SARDs, SERDs and Specific BET & DUB Inhibitors), Application (Healthcare) and Region.
On the basis of geography, the market of Targeted Protein Degradation has been segmented into South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Taiwan, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico). If we see Market by Therapeutic Area, the sub-segment i.e. Inflammatory Disorders will boost the Targeted Protein Degradation market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth. If we see Market by Route, the sub-segment i.e. Oral will boost the Targeted Protein Degradation market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth.
Market Leaders and their expansionary development strategies
On 26th April 2021, Evotec announced that Bristol Myers Squibb has exercised its option to extend its 2018 strategic drug discovery and development partnership in the field of targeted protein degradation. The collaboration employs Evotec’s PanOmics platform, which combines throughput proteomics, high throughput transcriptomics, and cell imaging with PanHunter, a data analysis platform
ON 22nd April 2021, PerkinElmer, Inc. announced that it is serving as a provider and co-developer of assays, instrument solutions, and expertise for the PROXIDRUGS Consortium which is zeroing in on research for proximity drugs or PROTACs (PROteolysis Targeting Chimeras). and On 6th December 2020, Roivant Sciences unveiled its targeted protein degradation platform which includes novel degraders for multiple diseases across oncology, immunology, and neurology.
Market Drivers
- The Growing Awareness Among The People Regarding The Benefits Of Protein Degradation Which Will Help In Boosting The Growth Of The Market
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- Increasing Demand for Protein Degradation for Drug Discovery Strategy to Treat Diseases Which Will Likely to Enhance The Growth Of The Targeted Protein Degradation
Opportunities
- The Growing Popularity And Interest In The Therapeutic Potential Of These Molecules Is Evident Across Modern Scientific Literature And Adoption Of These Therapeutics And Affiliated Technologies, Over The Next Decades
- The Technological Advancement And Developing Protein Degraders Research Want To Break Into That Ubiquitin-Proteasome Machinery To Change The Purpose Of Disease-Causing Proteins Is Booming The Opportunities Of Growth In The Market
Restraints
- High Protease Susceptibly and Low Cell Permeability will Likely to Hamper the Growth
Challenges
- Complex Structure and the Interactions between the E3 Ligase and The Target Protein
Key Target Audience
Government associations, Research organizations, Targeted Protein Degradation vendors and Others
About Approach
To evaluate and validate the market size various sources including primary and secondary analysis is utilized. AMA Research follows regulatory standards such as NAICS/SIC/ICB/TRCB, to have the better understanding of the market. The market study is conducted on basis of more than 200 companies dealing in the market regional as well as global areas with purpose to understand companys positioning regarding market value, volume and their market share for regional as well as global.
Further to bring relevance specific to any niche market we set and apply number of criteria like Geographic Footprints, Regional Segments of Revenue, Operational Centres, etc. The next step is to finalize a team (In-House + Data Agencies) who then starts collecting C & D level executives and profiles, Industry experts, Opinion leaders etc. and work towards appointment generation.
The primary research is performed by taking the interviews of executives of various companies dealing in the market as well as using the survey reports, research institute, and latest research reports. Meanwhile, analyst team keeps preparing set of questionnaires and after getting appointee list; the target audience are then tapped and segregated with various mediums and channels that are feasible for making connection that includes email communication, telephonic, skype, LinkedIn Group & InMail, Community Forums, Community Forums, open Survey, SurveyMonkey etc.